DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?
Identifieur interne : 001079 ( Main/Exploration ); précédent : 001078; suivant : 001080DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?
Auteurs : E. Florin [Allemagne, Canada] ; R. Erasmi [Allemagne] ; C. Reck [Allemagne] ; M. Maarouf [Allemagne] ; A. Schnitzler [Allemagne] ; G. R. Fink [Allemagne] ; L. Timmermann [Allemagne]Source :
- Neuroscience [ 0306-4522 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
Abstract
Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.
Affiliations:
- Allemagne, Canada
- District de Cologne, District de Düsseldorf, Québec, Rhénanie-du-Nord-Westphalie
- Cologne, Düsseldorf, Montréal
- Université McGill
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Maarouf</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A." last="Schnitzler">A. 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Fink</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neurology Section, Research Center Jülich, Leo-Brandt-Strasse 5</s1><s2>52425 Jülich</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>Leo-Brandt-Strasse 5</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L." last="Timmermann">L. 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Florin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neurology Section, Research Center Jülich, Leo-Brandt-Strasse 5</s1><s2>52425 Jülich</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>Leo-Brandt-Strasse 5</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, 3801 University St</s1><s2>Montreal, QC H3A 2B4</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC H3A 2B4</wicri:noRegion><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Erasmi, R" sort="Erasmi, R" uniqKey="Erasmi R" first="R." last="Erasmi">R. Erasmi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Reck, C" sort="Reck, C" uniqKey="Reck C" first="C." last="Reck">C. Reck</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Maarouf, M" sort="Maarouf, M" uniqKey="Maarouf M" first="M." last="Maarouf">M. Maarouf</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A." last="Schnitzler">A. Schnitzler</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University, Moorenstr. 5</s1><s2>40225 Düsseldorf</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurology, Heinrich-Heine-University, Moorenstr. 5</s1><s2>40225 Düsseldorf</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Fink, G R" sort="Fink, G R" uniqKey="Fink G" first="G. R." last="Fink">G. R. Fink</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neurology Section, Research Center Jülich, Leo-Brandt-Strasse 5</s1><s2>52425 Jülich</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>Leo-Brandt-Strasse 5</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L." last="Timmermann">L. Timmermann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62</s1><s2>50937 Köln</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Field potential</term><term>Human</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Potentiel champ</term><term>Maladie de Parkinson</term><term>Homme</term><term>Stimulation cérébrale profonde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>District de Cologne</li><li>District de Düsseldorf</li><li>Québec</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Cologne</li><li>Düsseldorf</li><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Florin, E" sort="Florin, E" uniqKey="Florin E" first="E." last="Florin">E. Florin</name></region><name sortKey="Erasmi, R" sort="Erasmi, R" uniqKey="Erasmi R" first="R." last="Erasmi">R. Erasmi</name><name sortKey="Fink, G R" sort="Fink, G R" uniqKey="Fink G" first="G. R." last="Fink">G. R. Fink</name><name sortKey="Fink, G R" sort="Fink, G R" uniqKey="Fink G" first="G. R." last="Fink">G. R. Fink</name><name sortKey="Florin, E" sort="Florin, E" uniqKey="Florin E" first="E." last="Florin">E. Florin</name><name sortKey="Maarouf, M" sort="Maarouf, M" uniqKey="Maarouf M" first="M." last="Maarouf">M. Maarouf</name><name sortKey="Reck, C" sort="Reck, C" uniqKey="Reck C" first="C." last="Reck">C. Reck</name><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A." last="Schnitzler">A. Schnitzler</name><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A." last="Schnitzler">A. Schnitzler</name><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L." last="Timmermann">L. Timmermann</name></country><country name="Canada"><region name="Québec"><name sortKey="Florin, E" sort="Florin, E" uniqKey="Florin E" first="E." last="Florin">E. Florin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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